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Hypertension Drugs May Be Helpful in Treating Multiple Sclerosis

Allison Gandey

Authors and Disclosures

August 20, 2009 — Early research has investigators questioning whether angiotensin-converting enzyme inhibitors may also have a role in treating autoimmune disorders such as multiple sclerosis. In a new study published online August 17 in the Proceedings of the National Academy of Sciences, researchers evaluated lisinopril in an animal model.

"When we treated mice with lisinopril given at standard doses, we could reverse paralysis," senior author Lawrence Steinman, MD, from Stanford University, Palo Alto, California told Medscape Neurology. "Who would have imagined that the angiotensin system could play such a decisive role in inflammation within the nervous system?"

The research team outlines how the renin-angiotensin-aldosterone system, which helps regulate blood pressure, also plays a major role in autoimmunity. Dr. Steinman is quick to point out that extensive clinical trial work is needed to determine whether lisinopril, or any other angiotensin-converting enzyme inhibitor, can do in humans what it does in mice, but he says he is excited about the possibility.

Current therapies for multiple sclerosis are expensive — some of the more popular monoclonal antibodies cost tens of thousands of dollars for each patient every year.

Major Health Implications

Marc Feldmann, MBBS, PhD, an immunologist at Imperial College London in the United Kingdom, said the results have major public health implications. "If multiple sclerosis patients can be treated with lisinopril at something like 1% of the price of treatment with natalizumab (Tysabri, Elan Pharmaceuticals) then far more patients will receive adequate therapy, at a substantially lower cost," he said in a news release. Professor Feldmann is familiar with the s